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Hemophilia and Rare Bleeding Disorders

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Overview Congenital FXIII deficiency is a very rare inherited bleeding disorder[1] caused by a lack of the protein clotting factor XIII (FXIII). In this disease, initial clot formation after...

What is hemophilia?
Hemophilia is a chronic, inherited bleeding disorder that primarily affects males. It is sex-linked, meaning that it is passed on from mother to child on the X chromosome. People with hemophilia A lack the Factor VIII protein and people with hemophilia B lack the Factor IX protein. These blood clotting proteins are essential for proper blood clotting. Because they are missing these factor proteins, people with hemophilia have a tendency to bleed longer than most. Another type of rare hemophilia that is not inherited is called acquired hemophilia (see acquired hemophilia below).

The term "bleeding disorders" refers to a range of diseases that interfere with the body's natural blood clotting process. Generally, a person with a bleeding disorder has a tendency to bleed for longer periods of time. Symptoms can include: